![]() ![]() However, the BBB also restricts access to large molecule therapeutics designed to treat central nervous system (CNS) disorders 6, 7. The blood-brain barrier (BBB) plays a critical role in maintaining the proper functioning of the brain by preventing the entry of most biomolecules 1, 2, 3, 4, 5. Our study establishes TV CD98hc as a modular brain delivery platform with favorable kinetic, biodistribution, and safety properties distinct from previously reported BBB platforms. Specific biodistribution profiles within the brain parenchyma can be modulated by introducing Fc mutations on ATV CD98hc that impact FcγR engagement, changing the valency of CD98hc binding, and by altering the extent of target engagement with Fabs. Compared to most existing BBB platforms targeting the transferrin receptor, peripherally administered ATV CD98hc demonstrates differentiated brain delivery with markedly slower and more prolonged kinetic properties. The pharmacokinetic and biodistribution properties of a CD98hc antibody transport vehicle (ATV CD98hc) are assessed in humanized CD98hc knock-in mice and cynomolgus monkeys. Here, we report the engineering and characterization of a BBB transport vehicle targeting the CD98 heavy chain (CD98hc or SLC3A2) of heterodimeric amino acid transporters (TV CD98hc). Nature Communications volume 14, Article number: 5053 ( 2023)īrain exposure of systemically administered biotherapeutics is highly restricted by the blood-brain barrier (BBB). ![]() Retrieved February 26, 2023.CD98hc is a target for brain delivery of biotherapeutics ^ a b Hearings before the Subcommittee to Investigate Juvenile Delinquency of the Committee on the Judiciary of the United States Senate: Eighty-Seventh Congress, First Session.^ Sculthorpe, Derek (October 4, 2018).Lou Grant: The Making of TV's Top Newspaper Drama. ^ a b c d e " 'Father of the Bride' Seen in Premiere".All Hands: The Bureau of Naval Personnel Information Bulletin. ^ "List of New Motion Pictures And TV Series Available To Ships and Overseas Bases".The Complete Directory to Prime Time Network and Cable TV Shows, 1946-Present. ^ a b c d e Brooks, Tim Marsh, Earle F.New York, New York: Penguin Books USA, Inc. Total Television: the Comprehensive Guide to Programming from 1948 to the Present (4th ed.). Teleplay by : Daniel Mainwaring & Harry Essex Teleplay by : Alexander Richards & Harry Essex Story by : David Chandler & Shimon Wincelberg Teleplay by : Ellis Marcus & Harold Callen Teleplay by : Palmer Thompson & Don Brinkley & Christopher Knopf On July 28, 1961, a hearing focused on violence and crime on television, especially with regard to their depiction when many children were watching. Target: The Corruptors! was considered as part of an investigation by the Subcommittee to Investigate Juvenile Delinquency of the Committee on the Judiciary of the United States Senate. In the opening episode, cameras used extreme closeups to show faces "in a way that projects them almost physically and uncomfortably into the living room." Senate hearing Sydney Pollack directed the episode "The Wreckers". Gene Roddenberry wrote for at least one episode. : 2368 The producers were Leonard Ackerman and John Burrows. The series was produced by Four Star Television. Dennis Cross as Reicher (recurring role).Jo Helton as Rose Vaclavic (recurring role).Cast Main cast Robert Harland as Jack Flood and Stephen McNally as Paul Marino ![]() After the show ended, Vielie had no explanation for its cancellation by ABC, especially considering its high Nielsen ratings. He added that involving viewers in contemporary situations that affected people's lives would be a unique approach for a dramatic series. Lester Vielie, one of the series's creators, said that the program was an attempt to make a different kind of series for television, one that combined "the resources of investigative journalism with the drama of television". The New York Times wrote that the first episode "indicated that the stress here may be more on violence and sensationalism than on the social phenomenon under study." In each episode they probe a different type of illegal activity such as bookmaking, charity scams, prostitution, and protection rackets. Together they investigate criminal activity and expose organized rackets and corruption. Paul Marino is a newspaper columnist, and Jack Flood is his assistant. The series's title in syndication was Expose. The Navy Motion Picture Service also made some episodes available on 16 mm film for showing aboard ship to personnel of the United States Navy. Target: The Corruptors! is an American crime drama series starring Stephen McNally that aired on ABC from Septemto September 21, 1962, from 10 to 11 p.m. ![]()
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